I was fortunate enough to get the third volume of Walter Simonson's run on Fantastic Four lately, which seems to be the segment with the most memorable portions, just based on what I've read. For one thing, it featured the New Fantastic Four.
It also featured this Spider-Man pinup by Art Adams, which has been the logo of one of my comics shops for as long as I've been buying comics.
It's got some meta-criticism of DC's approach to the multiverse.
It's got Justice Peace, making his second appearance since Walt used him in Thor.
Okay, fine, that last one isn't memorable. What is memorable is issue #352, where Reed Richards fights Dr. Doom, with both of them jumping around time. So there are two storylines running at the same time: Reed and Doom's fight, jumping around in time, and the rest of the Fantastic Four making their way through Doom's castle. So each page would have a "real time stamp" and a time stamp for Reed and Doom, indicating where they're going.
So, you could read it in the order of the timestamps, following the Thing and the Invisible Woman and the Human Torch, but with Reed and Doom jumping around (Click to enlarge):
Or you could use the timestamps to flip back and forth and read the Reed/Doom fight in the order in which it happens (these are the same three pages, but in the order of the Reed/Doom fight):
If you're so inclined, you end up doing both. You could try this on the screen, but you wouldn't be able to jump around without doing recuts. You could try it with the written word, but because it's not visual, you won't be able to take it in all at once. It's one of those fun things the medium excels in.
Does it have much practical application beyond time travel stories? Probably not, but that's why the issue still stands out 23 years later.